2/21/2023 0 Comments Cure my addiction chapter 1![]() ![]() ![]() Griffiths, a professor of neurology at Johns Hopkins in Baltimore strongly believes that caffeine withdrawal should be classified as a psychological disorder. ![]() Studies have demonstrated that people who take in a minimum of 100 mg of caffeine per day (about the amount in one cup of coffee) can acquire a physical dependence that would trigger withdrawal symptoms that include headaches, muscle pain and stiffness, lethargy, nausea, vomiting, depressed mood, and marked irritability. This delays the onset of drowsiness and releases dopamine. Caffeine dependence forms due to caffeine antagonizing the adenosine A2A receptor, effectively blocking adenosine from the adenosine receptor site. Caffeine, like addictive drugs, enhances dopamine signaling in the brain (is eugeroic), but not enough to activate the brain's reward circuit like addictive substances such as cocaine, morphine, and nicotine. For a drug to be considered addictive, it must activate the brain's reward circuit. Dependence Ĭaffeine use is classified as a dependence, not an addiction. Caffeine addiction, or a pathological and compulsive form of use, has been documented in humans. Mild physical dependence can result from long-term caffeine use. The Diagnostic and Statistical Manual of Mental Disorders describes four caffeine-related disorders including intoxication, withdrawal, anxiety, and sleep. Caffeine's ability to block these receptors means the levels of the body's natural stimulants, dopamine and norepinephrine, continue at higher levels. Adenosine is a by-product of cellular activity, and stimulation of adenosine receptors produces feelings of tiredness and the need to sleep. Caffeine is also an additive in many consumer products, including beverages such as caffeinated alcoholic beverages, energy drinks, and colas.Ĭaffeine's mechanism of action is somewhat different from that of cocaine and the substituted amphetamines caffeine blocks adenosine receptors A 1 and A 2A. Caffeine dependence is the condition of having a substance dependence on caffeine, a commonplace central nervous system stimulant drug which occurs in nature in coffee, tea, yerba mate, cocoa, and other plants. ![]()
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